Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its stepwise folding into the unique structure present in mature ribosomes.rRNA folding starts already co-transcriptionally in the nucleolus and continues when pre-ribosomal particles further maturate in the nucleolus and upon their transit to the nucleoplasm and cyto
Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion
Abstract Background Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways.Recent data have shown that MPL function is essential for CALR mutant-driven MPN.However, the exact role
What is the scope of conciliation in the plan of social ordering of property in Colombia?
In the framework of the final agreement for ending the conflict and building a stable and lasting peace in Colombia, chapter one, called Comprehensive Rural Reform, stipulated Horse Supplements the development and implementation of Plans for Social Management of Rural Property and Productive Land Use (POSPR in Spanish) under the modality of propert